BDBM50239780 CHEMBL4065365

SMILES COc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\OCC(O)CO)c2c1

InChI Key InChIKey=GIEDBGFYGHINFT-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50239780   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 43nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinE expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant Tyk2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant c-Src (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant Lyn (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase HCK(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant Hck (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant c-Src (unknown origin) incubated for 120 mins in presence of [33P]-ATP by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) incubated for 120 mins in presence of [33P]-ATP by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 74nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) incubated for 120 mins in presence of [33P]-ATP by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of recombinant TYK2 (unknown origin) incubated for 120 mins in presence of [33P]-ATP by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed