BDBM50239737 CHEMBL4094814::US10214537, Example 573

SMILES CC(=O)N1CCN(C(=O)C1(C)C)c1cc(ccc1C(F)(F)F)-c1cc(c2c(N)ncnn12)C(F)(F)F

InChI Key InChIKey=WZPCAKBVBITGNM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50239737   

LigandPNGBDBM50239737(US10214537, Example 573 | CHEMBL4094814)
Affinity DataIC50: 2nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
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LigandPNGBDBM50239737(US10214537, Example 573 | CHEMBL4094814)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50239737(US10214537, Example 573 | CHEMBL4094814)
Affinity DataIC50: 230nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-IgD-mediated B-cell activation by measuring decrease in CD19+ cells expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50239737(US10214537, Example 573 | CHEMBL4094814)
Affinity DataIC50: 82nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-CD3/anti-CD28-mediated IFNgamma production preincubated for 1 hr followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed