BDBM50239723 CHEMBL4074193::US10214537, Example 478

SMILES CC(C)c1nnc(o1)-c1cc(-c2cccc(c2)N2CCN(C(C)=O)C(C)(C)C2=O)n2ncnc(N)c12

InChI Key InChIKey=BZFYKNDIMPKFTP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50239723   

LigandPNGBDBM50239723(US10214537, Example 478 | CHEMBL4074193)
Affinity DataIC50: 1nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50239723(US10214537, Example 478 | CHEMBL4074193)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50239723(US10214537, Example 478 | CHEMBL4074193)
Affinity DataIC50: 140nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-IgD-mediated B-cell activation by measuring decrease in CD19+ cells expres...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed