BDBM50239559 CHEMBL4073594

SMILES CC1=CSC2=CC(=C(C(=O)N12)c3ccccc3)[C@H](C)Nc4c(c(ncn4)N)C#N

InChI Key InChIKey=XLCBQUCCOPILIO-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50239559   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50239559(CHEMBL4073594)Copy SMILESCopy InChI

Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/23/2019
Entry Details Article
Copy Entry DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50239559(CHEMBL4073594)Copy SMILESCopy InChI

Affinity DataIC50: 0.794nMAssay Description:Inhibition of PI3Kdelta in human JeKo1 cells assessed as reduction in Akt phosphorylation at Ser473 residue preincubated for 60 mins followed by Anti...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/23/2019
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50239559(CHEMBL4073594)Copy SMILESCopy InChI

Affinity DataIC50: 631nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/23/2019
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50239559(CHEMBL4073594)Copy SMILESCopy InChI

Affinity DataIC50: 0.398nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/23/2019
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50239559(CHEMBL4073594)Copy SMILESCopy InChI

Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/23/2019
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL