BDBM50238675 2,3,5,6-Tetramethyl-Pyrazine::2,3,5,6-Tetramethylpyrazine::Ligustrazine::Tetramethylpyrazine

SMILES Cc1nc(C)c(C)nc1C

InChI Key InChIKey=FINHMKGKINIASC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50238675   

TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50238675(2,3,5,6-Tetramethyl-Pyrazine | 2,3,5,6-Tetramethyl...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
TargetThioredoxin reductase 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50238675(2,3,5,6-Tetramethyl-Pyrazine | 2,3,5,6-Tetramethyl...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of thioredoxin reductase in human A549/CDDP cells by DTNB dye based microplate spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetThioredoxin reductase 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50238675(2,3,5,6-Tetramethyl-Pyrazine | 2,3,5,6-Tetramethyl...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of thioredoxin reductase in human A549 cells by DTNB dye based microplate spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetThioredoxin reductase 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50238675(2,3,5,6-Tetramethyl-Pyrazine | 2,3,5,6-Tetramethyl...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of thioredoxin reductase (unknown origin) after 2 hrs by DTNB dye based microplate spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed