BDBM50237809 CHEMBL126159::US20240287089, Compound LMP744

SMILES COc1cc2c3C(=O)c4cc5OCOc5cc4-c3n(CCCNCCO)c(=O)c2cc1OC

InChI Key InChIKey=QCSDJDQOJBQTDV-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50237809   

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50237809(CHEMBL126159 | US20240287089, Compound LMP744)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human Tdp2 assessed as decrease in alpha 32P-cordycepin-3'-labeled DNA breaks after 15 mins by PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50237809(CHEMBL126159 | US20240287089, Compound LMP744)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of recombinant Tdp1 (unknown origin) assessed as decrease in hydrolysis of phosphodiester linkage between tyrosine residue and the 3' end ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMyc proto-oncogene protein(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM50237809(CHEMBL126159 | US20240287089, Compound LMP744)
Affinity DataKd:  11nMAssay Description:MycG4 Stabilization Measured by FRET Melting. A F rster Resonance Energy Transfer (FRET)-melting assay was conducted in order to determine whether th...More data for this Ligand-Target Pair
In DepthDetails
US Patent