BDBM50237457 CHEMBL4097599

SMILES COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCc1ccnc(N)c1

InChI Key InChIKey=MXAZSKBTKUGBLI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50237457   

TargetGlutaminyl-peptide cyclotransferase(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50237457(CHEMBL4097599)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human glutaminyl cyclase assessed as reduction in conversion of H-Gln-AMC hydrobromide to pGlu-AMC preincubated with substrate for 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2019
Entry Details Article
PubMed
TargetGlutaminyl-peptide cyclotransferase-like protein(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50237457(CHEMBL4097599)
Affinity DataIC50: 502nMAssay Description:Inhibition of iso glutaminyl cyclase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2019
Entry Details Article
PubMed
TargetGlutaminyl-peptide cyclotransferase(Mouse)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50237457(CHEMBL4097599)
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse glutaminyl cyclase assessed as reduction in conversion of H-Gln-AMC hydrobromide to pGlu-AMC preincubated with substrate for 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2019
Entry Details Article
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50237457(CHEMBL4097599)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50237457(CHEMBL4097599)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed