BDBM50237288 CHEMBL4073198

SMILES COCCn1cc(NC(=O)c2csc(n2)-c2nncn2C(C)C)cn1

InChI Key InChIKey=NWXGFDVFXJMUDD-UHFFFAOYSA-N

Data  12 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50237288   

TargetCyclin-dependent kinase 2(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50237288(CHEMBL4073198)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50237288(CHEMBL4073198)
Affinity DataEC50:  60nMAssay Description:Inhibition of ASK1 (unknown origin) assessed as reduction in JNK phosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50237288(CHEMBL4073198)
Affinity DataIC50: 60nMAssay Description:Inhibition of ASK1 (unknown origin) using biotin-MBP as substrate after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50237288(CHEMBL4073198)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetEphrin type-A receptor 3(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50237288(CHEMBL4073198)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human His-tagged EPHA3 cytoplasmic domain (569 to 976 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50237288(CHEMBL4073198)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ERBB4 cytoplasmic domain (708 to 993 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50237288(CHEMBL4073198)
Affinity DataIC50: 457nMAssay Description:Inhibition of recombinant full length human His-tagged GSK3B expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50237288(CHEMBL4073198)
Affinity DataIC50: 7.59E+3nMAssay Description:Inhibition of recombinant human GST-tagged MER cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
LigandPNGBDBM50237288(CHEMBL4073198)
Affinity DataIC50: 794nMAssay Description:Inhibition of PRKAA1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50237288(CHEMBL4073198)
Affinity DataIC50: 617nMAssay Description:Inhibition of recombinant human GST-tagged RET cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50237288(CHEMBL4073198)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human GST-tagged RON cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50237288(CHEMBL4073198)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant full length human GST-tagged ITK expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50237288(CHEMBL4073198)
Affinity DataIC50: 5.37E+3nMAssay Description:Inhibition of recombinant human GST-tagged ROCK1 catalytic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed