BDBM50237002 CHEMBL4073356

SMILES COc1ccc(SCc2cnc(SCc3c(F)cc(cc3F)S(=O)(=O)\N=C\N(C)C)n2-c2ccc(F)cc2)cc1OC

InChI Key InChIKey=JGXLBGBDXORHDN-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50237002   

TargetG-protein coupled bile acid receptor 1(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50237002(CHEMBL4073356)
Affinity DataEC50:  590nMAssay Description:Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2019
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50237002(CHEMBL4073356)
Affinity DataEC50:  1.66E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2019
Entry Details Article
PubMed