BDBM50236544 CHEMBL4096575

SMILES Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1

InChI Key InChIKey=ATXGVVQAUKKFAN-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50236544   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Qimr Berghofer Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50236544(CHEMBL4096575)
Affinity DataIC50: 711nMAssay Description:Binding affinity to DYRK1A in human U251 cell lysate preincubated for 1 hr followed by incubation at 54 degreeC for 3 mins by isothermal dose-respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2019
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Qimr Berghofer Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50236544(CHEMBL4096575)
Affinity DataIC50: 43nMAssay Description:Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2019
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Qimr Berghofer Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50236544(CHEMBL4096575)
Affinity DataIC50: 567nMAssay Description:Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Qimr Berghofer Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50236544(CHEMBL4096575)
Affinity DataEC50:  3.40E+4nMAssay Description:Inhibition of CLK1 (unknown origin) using KKGRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2019
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Qimr Berghofer Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50236544(CHEMBL4096575)
Affinity DataIC50: 32nMAssay Description:Inhibition of DYRK1B (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Qimr Berghofer Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50236544(CHEMBL4096575)
Affinity DataIC50: 34nMAssay Description:Inhibition of human 130-end recombinant CLK1 assessed as remaining activity using ERMRPRKRQGSVR as substrate by [gamma-32P]ATP binding based scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Qimr Berghofer Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50236544(CHEMBL4096575)
Affinity DataIC50: 43nMAssay Description:Inhibition of human full length recombinant DYRK1A assessed as remaining activity using RRRFRPASPLRGPP as substrate by [gamma-32P]ATP binding based s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed