BDBM50235240 CHEMBL4065169

SMILES CS(=O)(=O)Nc1cccc(n1)[C@@H](C(c1cccnc1)c1cccnc1)c1ccc(F)cc1

InChI Key InChIKey=QPWKXYZJANVPLF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50235240   

TargetPotassium voltage-gated channel subfamily A member 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235240(CHEMBL4065169)
Affinity DataIC50: 11nMAssay Description:Inhibition of Kv1.5 mediated ultra-rapid delayed rectifier current Ikur in human atrial myocytes by voltage-patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235240(CHEMBL4065169)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in rapidly activating delayed rectifier cardiac potassium current by whole-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235240(CHEMBL4065169)
Affinity DataIC50: 790nMAssay Description:Inhibition of human KCNQ1/KCNE1 expressed in HEK293 cells assessed as reduction in slowly activating delayed rectifier cardiac potassium current by p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235240(CHEMBL4065169)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of [3H]-MK499 from human ERG IKr channel expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily D member 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235240(CHEMBL4065169)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of Kv4.3 (unknown origin) assessed as reduction in transient outward potassium current by high throughput clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235240(CHEMBL4065169)
Affinity DataIC50: 9nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed