BDBM50234074 CHEMBL4070633::US9701664, Example 39

SMILES Cc1ccc2cc(ccc2n1)C(=O)Nc1cc(NC(=O)c2ccc3OCCOc3c2)ccc1C

InChI Key InChIKey=RZQWMJAOUJLEAM-UHFFFAOYSA-N

Data  19 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50234074   

TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 68nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 23nMAssay Description:The cell titre blue viability (Promega, USA) assay provides a homogenous, fluorometric method for estimating the number of viable cells. It uses the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2023
Entry Details
Go to US Patent

TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 8nMAssay Description:U2OS cells (5-8×104 cells/mL) or SK-OV-3 cells (5-8×104 cells/mL) were seeded into 96-well plates and incubated at 37° C. for 48 h. Compounds were th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2023
Entry Details
Go to US Patent

TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 82nMAssay Description:U2OS cells (1500 per well) were plated in 40 μL of DMEM media (containing 10% fetal calf serum and 2 mM Glutamax T-1) in costar 384-well plates ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2023
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant human GST-tagged BRAF V600E mutant expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 44nMAssay Description:Displacement of 6-amino-9-(2-((4-((2-((6-((5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)carbamoyl)quinolin-2-yl)oxy)ethyl)amino)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 420nMAssay Description:Inhibition of recombinant human full length GST-tagged BRAF expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 44nMAssay Description:Displacement of 6-amino-9-(2-((4-((2-((6-((5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)carbamoyl)quinolin-2-yl)oxy)ethyl)amino)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor beta(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant His tagged PDGFRB cytoplasmic domain (556 to 1108 residues) expressed in baculovirus expression system using Tyr 04 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 420nMAssay Description:Inhibition of full length human recombinant GST-tagged BRAF (S429 to E741 residues) expressed in baculovirus expression system using Ser/Thr 03 mixtu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataKd:  38nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 68nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 417nMAssay Description:Inhibition of full length human recombinant GST-tagged BRAF (S429 to E741 residues) expressed in baculovirus expression system using Ser/Thr 03 mixtu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataKd:  38nMAssay Description:Binding affinity to recombinant human pirin by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor alpha(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GST tagged PDGFRA cytoplasmic domain expressed in baculovirus expression system using Tyr 04 as substrate after 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GST tagged PDGFRA cytoplasmic domain expressed in baculovirus expression system using Tyr 04 as substrate after 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant His tagged PDGFRB cytoplasmic domain (556 to 1108 residues) expressed in baculovirus expression system using Tyr 04 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KIT (unknown origin) using Tyr 06 as substrate after 1 hr by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KIT (unknown origin) using Tyr 06 as substrate after 1 hr by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human U20S cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human U20S cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed