BDBM50233160 CHEMBL4071490::US11124490, Compound 3h

SMILES Fc1cc(NC(=O)c2cc(c(Cl)cc2Cl)S(=O)(=O)N2CCOCC2)cc(F)c1C#N

InChI Key InChIKey=WEVFQGNWDVHNCZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50233160   

TargetAutotaxin(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50233160(CHEMBL4071490 | US11124490, Compound 3h)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant human C-terminal FLAg-tagged ATX lysophospholipase D activity expressed in baculovirus infected sf9 cells using FRET based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details Article
PubMed
TargetAutotaxin(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50233160(CHEMBL4071490 | US11124490, Compound 3h)
Affinity DataIC50: 190nMAssay Description:Compound 3b was found to be the most potent ATX inhibitor with an IC50 of about 9 nM. The mechanism of action was determined to be competitive; howev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent