BDBM50232621 CHEMBL4093284

SMILES COCc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1CCOc1cc(F)c(CC(=O)N2CCC2)c(F)c1

InChI Key InChIKey=QWNGDOXELSIKNT-UHFFFAOYSA-N

Data  3 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50232621   

LigandPNGBDBM50232621(CHEMBL4093284)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50232621(CHEMBL4093284)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human ERG by PatchXpress methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50232621(CHEMBL4093284)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50232621(CHEMBL4093284)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50232621(CHEMBL4093284)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at human PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50232621(CHEMBL4093284)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed