BDBM50230577 CHEMBL4095693

SMILES COc1cccc(c1)C1=NC(c2c(N1)n(-c1ccc(Cl)cc1)c(=O)[nH]c2=O)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=CAUAFWWOMUGIMM-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50230577   

TargetGlucagon receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50230577(CHEMBL4095693)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at glucagon receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50230577(CHEMBL4095693)
Affinity DataIC50: 5.89E+3nMAssay Description:Antagonist activity at human GLP-1R expressed in TREx293 cells co-expressing cAMP sensitive luciferase assessed as inhibition of GLP1 (7 to 36 residu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50230577(CHEMBL4095693)
Affinity DataIC50: 5.75E+3nMAssay Description:Antagonist activity at human GLP-1R expressed in TREx293 cells co-expressing cAMP sensitive luciferase assessed as inhibition of exendin-4-induced cA...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50230577(CHEMBL4095693)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 15 mins followed by NADPH addition measured after 8 min...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50230577(CHEMBL4095693)
Affinity DataIC50: 3.78E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 15 mins followed by NADPH addition measured after 8 min...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50230577(CHEMBL4095693)
Affinity DataIC50: 8.13E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 15 mins followed by NADPH addition measured after...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50230577(CHEMBL4095693)
Affinity DataIC50: 5.90E+3nMAssay Description:Antagonist activity at human GLP-1R expressed in TREx293 cells co-expressing cAMP sensitive luciferase assessed as inhibition of GLP1 (7 to 36 residu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50230577(CHEMBL4095693)
Affinity DataIC50: 5.80E+3nMAssay Description:Antagonist activity at human GLP-1R expressed in TREx293 cells co-expressing cAMP sensitive luciferase assessed as inhibition of exendin-4-induced cA...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50230577(CHEMBL4095693)
Affinity DataIC50: 1.64E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition measured after 8 mins...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed