BDBM50229973 (4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine::4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)thiazol-2-amine::CHEMBL298445::[4-(2-AMINO-4-METHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-(3-NITRO-PHENYL)-AMINE

SMILES Cc1nc(N)sc1-c1ccnc(Nc2cccc(c2)[N+]([O-])=O)n1

InChI Key InChIKey=DYTKVFHLKPDNRW-UHFFFAOYSA-N

Data  15 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50229973   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataIC50: 168nMAssay Description:Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataIC50: 188nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataIC50: 655nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataIC50: 10nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataIC50: 51nMAssay Description:Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataIC50: 145nMAssay Description:Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataKi:  2nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataKi:  2nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataKi:  4nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataKi:  4nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin) using (biotinyl-Ahx-(Tyr-Ser-ProThr-Ser-Pro-Ser)4-NH2 as substrate after 45 mins by [gamma-32P]ATP base...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataKi:  20nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4(Human)
University of South Australia Cancer Research Institute

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataKi:  53nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4(Human)
University of South Australia Cancer Research Institute

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataKi:  53nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataKi:  57nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataKi:  70nMAssay Description:Inhibition of Cdk7/cyclin HMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataKi:  70nMAssay Description:Inhibition of CDK7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase A(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataKi:  73nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of South Australia Cancer Research Institute

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataKi:  80nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of South Australia Cancer Research Institute

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataKi:  80nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataKi:  160nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataKi:  396nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed