BDBM50222205 (1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,11-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid::2-alpha-hydroxyursolic acid::2alpha,2beta-dihydroxy-18beta-ursan-12-ene-28-oic acid::2alpha,3beta-Dihydroxyurs-12-en-28-oic Acid::CHEMBL391533::Corosolic acid::US11660306, Example Corosolic acid

SMILES C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O

InChI Key InChIKey=HFGSQOYIOKBQOW-UHFFFAOYSA-N

Data  2 KI  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50222205   

TargetPancreatic alpha-amylase(Pig)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 3.12E+4nMAssay Description:Inhibition of porcine pancreatic alpha-amylase using starch as substrate preincubated for 15 mins followed by substrate addition measured after 10 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 2.27E+4nMAssay Description:Inhibition of human USP7 using human N-terminal GST-tagged UBA52 as substrate preincubated for 10 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosyl-DNA phosphodiesterase 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of TDP1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using 5'-FAM-AGGATCTAAAAGACTT-BHQ-3' as substrate preincubated for 30 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of ovine recombinant COX1 assessed as decrease in formation of PGE2 using arachidonic acid as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant 5-LOX expressed in insect cells assessed as decrease in production of 5-HPETE and 5-HETE using arachidonic acid as su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant 5-LOX expressed in insect cells assessed as decrease in production of 5-HPETE and 5-HETE using arachidonic acid as su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of ovine recombinant COX1 assessed as decrease in formation of PGE2 using arachidonic acid as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 5.49E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 5.49E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article

TargetDNA polymerase beta(Human)
Virginia Polytechnic Institute and State University

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of DNA polymerase beta lyase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human recombinant PTP1B using p-nitrophenyl phosphate as substrate assessed as p-nitrophenol release after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen phosphorylase, muscle form(Rabbit)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of rabbit muscle glycogen phosphorylase a assessed as glycogen synthesisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen phosphorylase, liver form(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibitory concentration against rat liver glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen phosphorylase, muscle form(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory concentration against rabbit muscle glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen phosphorylase, muscle form(Rabbit)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader bas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 810nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as reduction of cortisone to cortisol conversion by scintillation coun...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of TCPTP by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 5.49E+3nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase epsilon(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant PTPepsilonMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase alpha(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant PTPalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant LARMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataIC50: 2.46E+4nMAssay Description:Inhibition of human recombinant SHP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-405](Human)
Cold Spring Harbor Laboratory

US Patent
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataKi:  1.50E+3nMAssay Description:Glucose in tail blood was measured using a glucometer (One-Touch Basic; Lifescan, CA). For glucose tolerance tests (GTTs), mice were fasted for 10 ho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein phosphatase non-receptor type 1 [1-321](Human)
Cold Spring Harbor Laboratory

US Patent
LigandPNGBDBM50222205((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Affinity DataKi:  3.00E+3nMAssay Description:Glucose in tail blood was measured using a glucometer (One-Touch Basic; Lifescan, CA). For glucose tolerance tests (GTTs), mice were fasted for 10 ho...More data for this Ligand-Target Pair
In DepthDetails
US Patent