BDBM50222108 CHEMBL93028

SMILES CCN1CC2CC1CN2c1cc2N(C(=O)NCc2nc1Sc1ccc(F)cc1F)c1c(Cl)cccc1Cl

InChI Key InChIKey=HRQLIPAWEHEJGG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50222108   

TargetMitogen-activated protein kinase 11/12/13/14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50222108(CHEMBL93028)
Affinity DataIC50: 1.30nMAssay Description:Anti human TNF-alpha activity determined through TNF-alpha release was measured in the supernatants by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 13(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50222108(CHEMBL93028)
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against mouse Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50222108(CHEMBL93028)
Affinity DataIC50: 42nMAssay Description:Inhibition of LPS-induced release of TNF-alpha from human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2018
Entry Details Article
PubMed