BDBM50216689 2-cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide::CHEMBL224864::US20240174650, Compound AGK
SMILES Clc1ccc(Cl)c(c1)-c1ccc(\C=C(/C#N)C(=O)Nc2cccc3ncccc23)o1
InChI Key InChIKey=SVENPFFEMUOOGK-UHFFFAOYSA-N
Data 32 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 32 hits for monomerid = 50216689
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Affinity DataIC50: 3.54E+3nMAssay Description:Inhibition of human recombinant SIRT2 by Flour de Lys assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Affinity DataIC50: 4.60E+3nMAssay Description:The SIRT2 enzyme activity assay is established based on the published studies. Firstly, peptide segment Ac-Gln-Pro-Lys-[Lys-(Ac)]-AMC, the substrate ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human recombinant SIRT2 using fluorescent peptide substrate incubated for 1 hr in presence of NAD+ by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human SIRT1More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human SIRT2More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
Affinity DataIC50: 9.81E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibition of human recombinant SIRT3 using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human recombinant SIRT2 using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant SIRT1 using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of human recombinant SIRT1 expressed in Escherichia coli cells using acetylated Lys side chain amino acids 379-382 (Arg-His-Lys-Lys(Ac)) p...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
Technical University of Denmark
Curated by ChEMBL
Technical University of Denmark
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SIRT5More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of human recombinant SIRT2 expressed in Escherichia coli cells using acetylated Lys side chain amino acids 379-382 (Arg-His-Lys-Lys(Ac)) p...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of Sirt2More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of SIRT2More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of SirT2More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human recombinant SIRT2 using Fluor-de-Lys as substrate incubated for 60 mins prior to substrate addition measured after 60 mins by flu...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant SIRT1 by Flour de Lys assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant SIRT1 using fluorescent peptide substrate by fluorescent assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human recombinant SIRT2 using fluorescent peptide substrate by fluorescent assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant SIRT3 using fluorescent peptide substrate by fluorescent assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Affinity DataIC50: 1.39E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
Technical University of Denmark
Curated by ChEMBL
Technical University of Denmark
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human SIRT5 assessed as reduction in desuccinylase activity using KQTAR(SuK)STGGKA substrateMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human SIRT3More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human SIRT1More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of GST-tagged human recombinant SIRT2 (34 to 356 residues) expressed in Escherichia coli BL21 using Fluor de Lys-SIRT as substrate incubat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human recombinant SIRT2More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 5.28E+4nMAssay Description:Inhibition of catalytically active human SIRT3 (102 to 399 amino acids) expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-me...More data for this Ligand-Target Pair
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of full length human SIRT1 expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Institute of Psychiatry and Neuroscience of Paris
Curated by ChEMBL
Affinity DataIC50: 1.56E+3nMAssay Description:Inhibition of full length human SIRT2 expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibition of human recombinant SIRT3 using Fluor-de-Lys as substrate incubated for 60 mins prior to substrate addition measured after 60 mins by flu...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant SIRT1 using Fluor-de-Lys as substrate incubated for 60 mins prior to substrate addition measured after 60 mins by flu...More data for this Ligand-Target Pair