BDBM50214817 CHEMBL236757::N6-aminoadenosine

SMILES NNc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

InChI Key InChIKey=DGKZTAGCCXJUAT-UHFFFAOYSA-N

Data  7 KI  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50214817   

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50214817(N6-aminoadenosine | CHEMBL236757)
Affinity DataIC50: 2.32E+5nMAssay Description:Inhibition of human recombinant ribonucleotide reductase M2/M1 expressed in Escherichia coli BL21 (DE3) after 30 mins by [3H]CDP reduction methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2 B(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50214817(N6-aminoadenosine | CHEMBL236757)
Affinity DataIC50: 2.44E+5nMAssay Description:Inhibition of human recombinant ribonucleotide reductase p53R2/M1 expressed in Escherichia coli BL21 (DE3) after 30 mins by [3H]CDP reduction methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetEndoplasmin(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50214817(N6-aminoadenosine | CHEMBL236757)
Affinity DataKd: >5.00E+4nMAssay Description:Displacement of FITC-geldanamycin from GRP94 (unknown origin) after 24 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50214817(N6-aminoadenosine | CHEMBL236757)
Affinity DataKd: >5.00E+4nMAssay Description:Displacement of FITC-geldanamycin from HSP90alpha (unknown origin) after 24 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50214817(N6-aminoadenosine | CHEMBL236757)
Affinity DataKi: >3.00E+3nMAssay Description:Displacement of FITC-geldanamycin from HSP90alpha (unknown origin) after 24 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50214817(N6-aminoadenosine | CHEMBL236757)
Affinity DataKi:  7.34E+3nMAssay Description:Displacement of [3H]-CGS- 21680 from Adenosine A2 receptor of rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article

TargetAdenosine receptor A2a(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50214817(N6-aminoadenosine | CHEMBL236757)
Affinity DataKi:  7.34E+3nMAssay Description:Binding affinity to adenosine A2A receptor in rat striatal membranes by measuring displacement of specific [3H]-CGS- 21680 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetEndoplasmin(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50214817(N6-aminoadenosine | CHEMBL236757)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of FITC-geldanamycin from GRP94 (unknown origin) after 24 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetAdenosine receptor A3(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50214817(N6-aminoadenosine | CHEMBL236757)
Affinity DataKi:  1.69E+4nMAssay Description:Binding affinity determined by displacement of specific binding of [125I]N-(4-amino-3-iodophenethyl)-adenosine in membranes of CHO cells stably trans...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50214817(N6-aminoadenosine | CHEMBL236757)
Affinity DataKi:  2.97E+4nMAssay Description:Binding affinity at Adenosine A1 receptor in rat brain membranes by [3H](R)-PIA displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article

TargetAdenosine receptor A1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50214817(N6-aminoadenosine | CHEMBL236757)
Affinity DataKi:  2.97E+4nMAssay Description:Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed