BDBM50213232 1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one::2'-hydroxy-4,4'-dimethoxychalcone::CHEMBL229907

SMILES COc1ccc(\C=C\C(=O)c2ccc(OC)cc2O)cc1

InChI Key InChIKey=OAAPAFSEMHJNTF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50213232   

LigandPNGBDBM50213232(1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)p...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50213232(1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)p...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of BCRP in human MCF7/MX cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by FluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50213232(1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)p...)
Affinity DataIC50: 3.52E+5nMAssay Description:Inhibition of human aromataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50213232(1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)p...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of amyloid beta (1-42) self-mediated aggregation (unknown origin) after 5 days by thioflavin T fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed