BDBM50210305 1-(3-(4-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno-[1,2-c]pyrazol-3-yl)thiophen-2-yl)prop-2-ynyl)-3-phenylurea::CHEMBL225336

SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCNC(=O)Nc3ccccc3)c2)CC1

InChI Key InChIKey=GLIHHDLJQYXTMG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50210305   

TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210305(1-(3-(4-(6-((4-methylpiperazin-1-yl)methyl)-1,4-di...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human KDR kinase by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210305(1-(3-(4-(6-((4-methylpiperazin-1-yl)methyl)-1,4-di...)
Affinity DataIC50: 7.91E+3nMAssay Description:Inhibition of hERG expressed in HEK293 cells assessed as effect on ionic current by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210305(1-(3-(4-(6-((4-methylpiperazin-1-yl)methyl)-1,4-di...)
Affinity DataIC50: 15nMAssay Description:Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed