BDBM50210162 CHEMBL3883534

SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C

InChI Key InChIKey=TUYDDIWQXWTNSW-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50210162   

TargettRNA-dihydrouridine(20) synthase [NAD(P)+]-like(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50210162(CHEMBL3883534)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of PF-06422899 binding to recombinant C-terminal FLAG-tagged DUS2L (unknown origin) expressed in HEK293T cells after 1 hr by gel-based ABP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50210162(CHEMBL3883534)
Affinity DataIC50: 7nMAssay Description:Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50210162(CHEMBL3883534)
Affinity DataIC50: 1nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50210162(CHEMBL3883534)
Affinity DataIC50: 1nMAssay Description:Inhibition of EGFR exon 19 deletion mutant phosphorylation in human PC9 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50210162(CHEMBL3883534)
Affinity DataIC50: 6nMAssay Description:Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A549 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by san...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50210162(CHEMBL3883534)
Affinity DataKi:  0.140nMAssay Description:Inhibition of PF-06422899 binding to EGFR in human A431 cells after 1 hr by gel-based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed