BDBM50209206 (2-ethylbenzofuran-3-yl)(4-hydroxy-3,5-diiodophenyl)methanone::CHEMBL232201::US9725430, Compound 1c::US9962362, Compound 1c

SMILES CCc1oc2ccccc2c1C(=O)c1cc(I)c(O)c(I)c1

InChI Key InChIKey=CZCHIEJNWPNBDE-UHFFFAOYSA-N

Data  3 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50209206   

TargetBaculoviral IAP repeat-containing protein 5(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50209206((2-ethylbenzofuran-3-yl)(4-hydroxy-3,5-diiodopheny...)
Affinity DataKd:  8.00E+3nMAssay Description:Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEyes absent homolog 3(Human)
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM50209206((2-ethylbenzofuran-3-yl)(4-hydroxy-3,5-diiodopheny...)
Affinity DataIC50: 3.40E+3nMAssay Description:An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetEyes absent homolog 3(Human)
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM50209206((2-ethylbenzofuran-3-yl)(4-hydroxy-3,5-diiodopheny...)
Affinity DataIC50: 3.40E+3nMAssay Description:The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
Go to US Patent

TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50209206((2-ethylbenzofuran-3-yl)(4-hydroxy-3,5-diiodopheny...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of acid mediated TTR V30M mutant aggregation (unknown origin) expressed in Escherichia coli preincubated for 30 mins followed by acetic bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50209206((2-ethylbenzofuran-3-yl)(4-hydroxy-3,5-diiodopheny...)
Affinity DataKd:  410nMAssay Description:Binding affinity to thyroxin binding site of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as quenching of intrinsic trypto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)