BDBM50207645 CHEMBL3971179

SMILES C[C@@H](N([C@@H](C(N)=O)c1ccccc1)C(=O)c1ccccc1)c1cc(F)cc(F)c1

InChI Key InChIKey=NNXPFEMWLZLAHM-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50207645   

LigandPNGBDBM50207645(CHEMBL3971179)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium increase by Fluo-4 AM ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2018
Entry Details Article
PubMed
LigandPNGBDBM50207645(CHEMBL3971179)
Affinity DataIC50: 80nMAssay Description:Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2018
Entry Details Article
PubMed
LigandPNGBDBM50207645(CHEMBL3971179)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human recombinant TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced calcium increase by Fluo-4 AM based a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2018
Entry Details Article
PubMed
LigandPNGBDBM50207645(CHEMBL3971179)
Affinity DataIC50: 89nMAssay Description:Antagonist activity at rat recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2018
Entry Details Article
PubMed
LigandPNGBDBM50207645(CHEMBL3971179)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human recombinant TRPA1 expressed in HEK293 cells assessed as increase in calcium flux by Fluo-4-AM based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2018
Entry Details Article
PubMed
LigandPNGBDBM50207645(CHEMBL3971179)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human recombinant TRPV4 expressed in HEK293 cells assessed as inhibition of RN-1747-induced calcium increase by Fura-2 AM base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2018
Entry Details Article
PubMed
LigandPNGBDBM50207645(CHEMBL3971179)
Affinity DataIC50: 80nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50207645(CHEMBL3971179)
Affinity DataEC50:  1.03E+4nMAssay Description:Activation of human PXR ligand binding domain incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed