BDBM50207120 3-isobutyl-8-((6-methoxyisoquinolin-4-yl)methyl)-1-methyl-1H-purine-2,6(3H,7H)-dione::CHEMBL246470::CHEMBL537889

SMILES COc1ccc2cncc(Cc3nc4n(CC(C)C)c(=O)n(C)c(=O)c4[nH]3)c2c1

InChI Key InChIKey=NMTKJEZOWHRAQY-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50207120   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(CHEMBL246470 | CHEMBL537889 | 3-isobutyl-8-((6-met...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(CHEMBL246470 | CHEMBL537889 | 3-isobutyl-8-((6-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PDE7A by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(CHEMBL246470 | CHEMBL537889 | 3-isobutyl-8-((6-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PDE4D by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(CHEMBL246470 | CHEMBL537889 | 3-isobutyl-8-((6-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PDE4B by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(CHEMBL246470 | CHEMBL537889 | 3-isobutyl-8-((6-met...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of adenosine A1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed