BDBM50206957 CHEMBL3902584::US9518055, Example 35

SMILES Fc1ccc2nc(c(C3CC3)n2c1)-c1cncc(c1)C(F)(F)F

InChI Key InChIKey=IRYAGXNONLSWLK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50206957   

TargetCytochrome P450 11B1, mitochondrial(Human)
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206957(CHEMBL3902584 | US9518055, Example 35)
Affinity DataIC50: 590nMAssay Description:Inhibition of human CYP11B1-8C7 expressed in Chinese hamster V79 cells using 11-deoxycortisol as substrate preincubated for 1 hr followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2018
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206957(CHEMBL3902584 | US9518055, Example 35)
Affinity DataIC50: 10nMAssay Description:Inhibition of human CYP11B2-CLE9 expressed in Chinese hamster V79 cells using 11-deoxycorticosterone as substrate preincubated for 1 hr followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2018
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206957(CHEMBL3902584 | US9518055, Example 35)
Affinity DataIC50: 7.10nMAssay Description:V79 cell lines stably expressing the either the human CYP11B2 or the human CYP11B1 enzyme were generated using a standard transfection protocol. V79 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206957(CHEMBL3902584 | US9518055, Example 35)
Affinity DataIC50: 1.02E+3nMAssay Description:V79 cell lines stably expressing the either the human CYP11B2 or the human CYP11B1 enzyme were generated using a standard transfection protocol. V79 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent