BDBM50206448 CHEMBL3944542

SMILES CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O

InChI Key InChIKey=CMOJHDQJJPIVEC-UHFFFAOYSA-N

Data  4 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50206448   

TargetSerine/threonine-protein kinase PLK1(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50206448(CHEMBL3944542)
Affinity DataIC50: 2.94E+4nMAssay Description:Inhibition of 5-FAM-DPPLHSpTAI-OH binding to PLK1 polo-box domain (unknown origin) expressed in Escherichia coli Rosetta (DE3) after 1 hr by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2018
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50206448(CHEMBL3944542)
Affinity DataKd:  1.05E+4nMAssay Description:Binding affinity to NT-647 labeled PLK1 polo-box domain (unknown origin) expressed in Escherichia coli Rosetta (DE3) by microscale thermophoresis bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2018
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50206448(CHEMBL3944542)
Affinity DataKd:  3.57E+4nMAssay Description:Binding affinity to GST-tagged PLK1 PBD (327 to 603 residues) (unknown origin) by NT-647 dye-based microscale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50206448(CHEMBL3944542)
Affinity DataKd:  8.73E+4nMAssay Description:Binding affinity to GST-tagged PLK2 PBD (355 to 685 residues) (unknown origin) by NT-647 dye-based microscale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50206448(CHEMBL3944542)
Affinity DataKd:  2.96E+5nMAssay Description:Binding affinity to GST-tagged PLK3 PBD (335 to 646 residues) (unknown origin) by NT-647 dye-based microscale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50206448(CHEMBL3944542)
Affinity DataKd:  4.08E+5nMAssay Description:Binding affinity to GST-tagged PLK1 PBD W414A mutant (unknown origin) by NT-647 dye-based microscale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50206448(CHEMBL3944542)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of 5-carboxyfluoresceinGPMQSpTPLNG-OH peptide binding to human PLK1 (326 to 603 residues) PBD expressed in Rosetta BL21 (DE3) cells preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50206448(CHEMBL3944542)
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of 5-carboxyfluorescein-GPMQTSpTPKNG-OH peptide binding to C-terminal 6His-tagged human PLK2 (355 to 685 residues) PBD expressed in Rosett...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50206448(CHEMBL3944542)
Affinity DataIC50: 5.39E+4nMAssay Description:Inhibition of 5-carboxyfluorescein-GPLATSpTPKNG-OH peptide binding to N-terminal MBP-tagged human PLK3 (335 to 646 residues) PBD expressed in Rosetta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed