BDBM50204719 4-(6-(((1r,4r)-4-hydroxycyclohexyl)carbamoyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid::CHEMBL242523

SMILES O[C@H]1CC[C@@H](CC1)NC(=O)c1ccc-2c(Cc3c(n[nH]c-23)-c2ccc(cc2)C(O)=O)c1

InChI Key InChIKey=IZDSHDSXSNHJNL-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50204719   

TargetSerine/threonine-protein kinase Chk1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204719(4-(6-(((1r,4r)-4-hydroxycyclohexyl)carbamoyl)-1,4-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant CHK1 assessed as human Cdc25C phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204719(4-(6-(((1r,4r)-4-hydroxycyclohexyl)carbamoyl)-1,4-...)
Affinity DataEC50: >5.90E+4nMAssay Description:Antiproliferative activity against human SW620 cells by soft agar assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed