BDBM50204715 4'-(6-{[(5-methyl-pyrazin-2-ylmethyl)-amino]-methyl}-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol::CHEMBL242536

SMILES Cc1cnc(CNCc2ccc-3c(Cc4c(n[nH]c-34)-c3ccc(cc3)-c3ccc(O)cc3)c2)cn1

InChI Key InChIKey=WZEQQBUDSLBCJT-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50204715   

TargetSerine/threonine-protein kinase Chk1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204715(4'-(6-{[(5-methyl-pyrazin-2-ylmethyl)-amino]-methy...)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of recombinant CHK1 assessed as human Cdc25C phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204715(4'-(6-{[(5-methyl-pyrazin-2-ylmethyl)-amino]-methy...)
Affinity DataEC50:  4.00E+3nMAssay Description:Antiproliferative activity against human SW620 cells by soft agar assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed