BDBM50203542 CHEMBL3218921

SMILES OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2Cl)c2ccccc12

InChI Key InChIKey=YRLYJWZLPGDXGP-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50203542   

TargetRetinoic acid receptor gamma(Human)
Galderma R & D

Curated by ChEMBL
LigandPNGBDBM50203542(CHEMBL3218921)
Affinity DataIC50: 1.30E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2018
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Galderma R & D

Curated by ChEMBL
LigandPNGBDBM50203542(CHEMBL3218921)
Affinity DataIC50: 60nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RORgammat LBD (unknown origin) expressed in HG5LN cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2018
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Galderma R & D

Curated by ChEMBL
LigandPNGBDBM50203542(CHEMBL3218921)
Affinity DataIC50: 2nMAssay Description:Inverse agonist activity at GST-tagged RORgammat LBD (unknown origin) using fluorescein-D22 co-activator peptide as substrate incubated for 1 hr by T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Mouse)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50203542(CHEMBL3218921)
Affinity DataIC50: 43nMAssay Description:Inverse agonist activity at RORgammat in mouse splenocytes derived naive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Galderma R & D

Curated by ChEMBL
LigandPNGBDBM50203542(CHEMBL3218921)
Affinity DataIC50: 20nMAssay Description:Transactivation of recombinant GAL4-DBD fused RORgammat LBD (unknown origin) expressed in HEK293T cells incubated for 18 to 24 hrs by dual-Glo lucife...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Galderma R & D

Curated by ChEMBL
LigandPNGBDBM50203542(CHEMBL3218921)
Affinity DataIC50: 5nMAssay Description:Allosteric inhibition of recombinant His6-tagged RORgammat LBD (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Galderma R & D

Curated by ChEMBL
LigandPNGBDBM50203542(CHEMBL3218921)
Affinity DataIC50: 400nMAssay Description:Allosteric inhibition of yeast GAL4 DNA domain-fused RORgammat LBD (97 to 518 residues) (unknown origin) expressed in HEK293T cells after 20 to 22 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed