BDBM50202277 (S)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid::2-[5-(4-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]-3-phenylpropanoic acid::CHEMBL243190::Thiazolidinone core, 24

SMILES OC(=O)[C@H](Cc1ccccc1)N1C(=S)S\C(=C/c2ccc(Br)cc2)C1=O

InChI Key InChIKey=NWNRPXAZPNUBGV-UHFFFAOYSA-N

Data  5 KI  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50202277   

TargetUDP-galactopyranose mutase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Wisconsin-Madison

LigandPNGBDBM50202277(Thiazolidinone core, 24 | 2-[5-(4-bromobenzylidene...)
Affinity DataIC50: 3.50E+4nM Kd:  9.30E+3nMAssay Description:To access the ability of compounds to inhibit the catalytic activity of UGM, an HPLC assay was employed. Inhibition constants were determined by mon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2011
Entry Details Article
PubMed
TargetUDP-galactopyranose mutase(Pseudomonas aeruginosa (g-Proteobacteria))
University of Wisconsin-Madison

LigandPNGBDBM50202277(Thiazolidinone core, 24 | 2-[5-(4-bromobenzylidene...)
Affinity DataKd: >3.30E+4nMAssay Description:To access the ability of compounds to inhibit the catalytic activity of UGM, an HPLC assay was employed. Inhibition constants were determined by mon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2011
Entry Details Article
PubMed
TargetBcl2-associated agonist of cell death(Human)
University of Minnesota Minneapolis

Curated by ChEMBL
LigandPNGBDBM50202277(Thiazolidinone core, 24 | 2-[5-(4-bromobenzylidene...)
Affinity DataKi:  5.25E+3nMAssay Description:Inhibition of Bak peptide binding to human recombinant Bcl-XlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50202277(Thiazolidinone core, 24 | 2-[5-(4-bromobenzylidene...)
Affinity DataKi:  1.42E+4nMAssay Description:Displacement of Flu-Bak peptide from recombinant antiapoptotic Bcl2 protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50202277(Thiazolidinone core, 24 | 2-[5-(4-bromobenzylidene...)
Affinity DataKi:  1.42E+4nMAssay Description:Inhibition of Bak peptide binding to human recombinant Bcl2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50202277(Thiazolidinone core, 24 | 2-[5-(4-bromobenzylidene...)
Affinity DataKi:  2.15E+4nMAssay Description:Displacement of Flu-Bak peptide from recombinant antiapoptotic Bcl-w protein by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50202277(Thiazolidinone core, 24 | 2-[5-(4-bromobenzylidene...)
Affinity DataKi:  2.15E+4nMAssay Description:Inhibition of Bak peptide binding to human recombinant Bcl-wMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed