BDBM50201641 CHEMBL3923175

SMILES CCS(=O)(=O)c1cc(Nc2ncc(F)c(n2)N(Cc2ccccc2C#N)c2cc(CO)ccc2C)ccc1N1CCN(C)CC1

InChI Key InChIKey=WPFLVPJXKWCRQK-UHFFFAOYSA-N

Data  10 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50201641   

TargetTyrosine-protein kinase Fyn(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataIC50: 45nMAssay Description:Inhibition of N-Terminal His6-tagged full length recombinant human FYN expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal 6His-tagged recombinant human PAK2 (3-end residues) expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataIC50: 59nMAssay Description:Inhibition of PAK1 phosphorylation in human MCF10A cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataIC50: 36nMAssay Description:Inhibition of N-terminal 6His-tagged full length recombinant human LCK expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataIC50: 7nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant full length human PKCtheta expressed in fall armyworm Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal FLAG-tagged recombinant human PAK1 (150-end residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataKd:  0.280nMAssay Description:Binding affinity to human PAK1 (S149 to H545 residues) expressed in bacterial expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataIC50: 31nMAssay Description:Inhibition of N-terminal his6-tagged recombinant full-length human LYN expressed in baculovirus infected Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of PAK1 (unknown origin) by ATP-kinaseGlo assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataKd:  0.320nMAssay Description:Binding affinity to human PAK2 (P151 to R525 residues) expressed in bacterial expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataIC50: 93nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human Src (1 to 530 residues) expressed in baculovirus infected sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal 6His-tagged full length recombinant human YES expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed