BDBM50201025 CHEMBL3975087::US10155727, Example 26::USRE49517, Example 26

SMILES FC(F)c1cc(ccc1Cl)-c1cnn(Cc2cc[nH]n2)c1

InChI Key InChIKey=GPZNPXAPAFLRLB-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50201025   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201025(CHEMBL3975087 | US10155727, Example 26 | USRE49517...)
Affinity DataIC50: 4.75E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201025(CHEMBL3975087 | US10155727, Example 26 | USRE49517...)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201025(CHEMBL3975087 | US10155727, Example 26 | USRE49517...)
Affinity DataIC50: 890nMAssay Description:Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201025(CHEMBL3975087 | US10155727, Example 26 | USRE49517...)
Affinity DataIC50: 30.1nMAssay Description:After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4° C. The pellet was resuspended in 5 ml of 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201025(CHEMBL3975087 | US10155727, Example 26 | USRE49517...)
Affinity DataIC50: 890nMAssay Description:The medium was removed and the cells were loaded with 200 μl loading buffer (Molecular Devices) in Mg2+-free HBPS containing 100 μM 7-CKA a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201025(CHEMBL3975087 | US10155727, Example 26 | USRE49517...)
Affinity DataIC50: 30.1nMAssay Description:After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201025(CHEMBL3975087 | US10155727, Example 26 | USRE49517...)
Affinity DataIC50: 4.75E+3nMAssay Description:Binding was terminated by filtration of the incubated membrane preparations using Filtermat B (Pharmacia, Uppsala Sweden) and a Micro Cell Harvester ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent