BDBM50200973 CHEMBL3897548::US10087187, Compound 1

SMILES CN(CCS(C)(=O)=O)Cc1nc2c(N)cc(nn2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1

InChI Key InChIKey=VMSCVSQPPSKFDR-UHFFFAOYSA-N

Data  2 IC50  10 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50200973   

LigandPNGBDBM50200973(CHEMBL3897548 | US10087187, Compound 1)
Affinity DataKd: >3.02E+4nMAssay Description:Binding affinity to human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50200973(CHEMBL3897548 | US10087187, Compound 1)
Affinity DataIC50: 34nMAssay Description:Inhibition of PI3Kbeta in human PC3 cells assessed as suppression of AKT phosphorylation at Ser473 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50200973(CHEMBL3897548 | US10087187, Compound 1)
Affinity DataIC50: 41nMAssay Description:Inhibition of PI3Kbeta in human PC3 cells assessed as suppression of AKT phosphorylation at Thr308 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50200973(CHEMBL3897548 | US10087187, Compound 1)
Affinity DataKd:  513nMAssay Description:Binding affinity to human PI3Kdelta (108 to 1044 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50200973(CHEMBL3897548 | US10087187, Compound 1)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to human PI3Kbeta (118 to 1070 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50200973(CHEMBL3897548 | US10087187, Compound 1)
Affinity DataKd:  2.34E+4nMAssay Description:Binding affinity to human MTOR (1382 to 2549 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50200973(CHEMBL3897548 | US10087187, Compound 1)
Affinity DataKd:  1.66E+4nMAssay Description:Binding affinity to human PI3Kalpha (108 to 1068 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50200973(CHEMBL3897548 | US10087187, Compound 1)
Affinity DataKd:  513nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50200973(CHEMBL3897548 | US10087187, Compound 1)
Affinity DataKd:  1.66E+4nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50200973(CHEMBL3897548 | US10087187, Compound 1)
Affinity DataKd:  2.40nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50200973(CHEMBL3897548 | US10087187, Compound 1)
Affinity DataKd: >3.02E+4nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50200973(CHEMBL3897548 | US10087187, Compound 1)
Affinity DataKd:  2.34E+4nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In DepthDetails
US Patent