BDBM50200972 CHEMBL3974658::US10087187, Compound 22
SMILES Cc1c(Cc2c(CO)nc3c(cc(nn23)N2CCOCC2)C(O)=O)cccc1C(F)(F)F
InChI Key InChIKey=QPCSZDZDHHSVIP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50200972
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Dart Neuroscience
Curated by ChEMBL
Dart Neuroscience
Curated by ChEMBL
Affinity DataIC50: 513nMAssay Description:Inhibition of PI3Kbeta in human PC3 cells assessed as suppression of AKT phosphorylation at Thr308 after 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataKd: 1.07E+4nMAssay Description:Binding affinity to human MTOR (1382 to 2549 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Dart Neuroscience
Curated by ChEMBL
Dart Neuroscience
Curated by ChEMBL
Affinity DataKd: >1.51E+4nMAssay Description:Binding affinity to human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Dart Neuroscience
Curated by ChEMBL
Dart Neuroscience
Curated by ChEMBL
Affinity DataKd: 48nMAssay Description:Binding affinity to human PI3Kdelta (108 to 1044 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Dart Neuroscience
Curated by ChEMBL
Dart Neuroscience
Curated by ChEMBL
Affinity DataIC50: 513nMAssay Description:Inhibition of PI3Kbeta in human PC3 cells assessed as suppression of AKT phosphorylation at Ser473 after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Dart Neuroscience
Curated by ChEMBL
Dart Neuroscience
Curated by ChEMBL
Affinity DataKd: 1.59E+3nMAssay Description:Binding affinity to human PI3Kalpha (108 to 1068 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Dart Neuroscience
Curated by ChEMBL
Dart Neuroscience
Curated by ChEMBL
Affinity DataKd: 1.20nMAssay Description:Binding affinity to human PI3Kbeta (118 to 1070 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha(Human)
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataKd: 1.59E+3nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta(Human)
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataKd: 1.20nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Dart Neuroscience
Curated by ChEMBL
Dart Neuroscience
Curated by ChEMBL
Affinity DataKd: 48nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Dart Neuroscience
Curated by ChEMBL
Dart Neuroscience
Curated by ChEMBL
Affinity DataKd: >1.51E+4nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Affinity DataKd: 1.07E+4nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair