BDBM50200554 CHEMBL3968765

SMILES FC(F)(F)c1ccc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)cc1

InChI Key InChIKey=UTNIELHSQXTLFN-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50200554   

TargetCaspase-1(Human)
Depaul University

Curated by ChEMBL
LigandPNGBDBM50200554(CHEMBL3968765)
Affinity DataIC50: 639nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Depaul University

Curated by ChEMBL
LigandPNGBDBM50200554(CHEMBL3968765)
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-5(Human)
Depaul University

Curated by ChEMBL
LigandPNGBDBM50200554(CHEMBL3968765)
Affinity DataIC50: 586nMAssay Description:Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-5(Human)
Depaul University

Curated by ChEMBL
LigandPNGBDBM50200554(CHEMBL3968765)
Affinity DataKi:  135nMAssay Description:Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-1(Human)
Depaul University

Curated by ChEMBL
LigandPNGBDBM50200554(CHEMBL3968765)
Affinity DataKi:  183nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-1 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Depaul University

Curated by ChEMBL
LigandPNGBDBM50200554(CHEMBL3968765)
Affinity DataKi:  563nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed