BDBM50200533 CHEMBL3904539

SMILES N[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F

InChI Key InChIKey=FAZMPKDPEUFZHA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50200533   

TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50200533(CHEMBL3904539)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant Pim2 (unknown origin) by electrochemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
LigandPNGBDBM50200533(CHEMBL3904539)
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of radiolabeled dofetilide binding to human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
LigandPNGBDBM50200533(CHEMBL3904539)
Affinity DataIC50: 115nMAssay Description:Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50200533(CHEMBL3904539)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed