BDBM50199033 5-[(5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL)-1-METHYL-2,4-DIOXO-1,3,7-TRIAZASPIRO [4.4]NON-7-YL]METHYL]-3-THIOPHENECARBOXYLICACID::5-[(5S,9R)-9-(4-Ccanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro [4.4]non-7-yl]methyl]-3-thiophenecarboxylicacid::6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid::CHEMBL214529::CHEMBL539342

SMILES CN1C(=O)N(C(=O)[C@]11CN(Cc2cc(cs2)C(O)=O)C[C@H]1c1ccc(cc1)C#N)c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=NXNKJLOEGWSJGI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50199033   

TargetIntegrin alpha-L(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50199033(CHEMBL539342 | CHEMBL214529 | 6-((5S,9R)-9-(4-cyan...)
Affinity DataIC50: 18nMAssay Description:Inhibition of LFA1-mediated adhesion of human T cells to ICAM1-expressing HUVEC by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50199033(CHEMBL539342 | CHEMBL214529 | 6-((5S,9R)-9-(4-cyan...)
Affinity DataIC50: 276nMAssay Description:Inhibition of LFA1-mediated IL2 mRNA level in SEB-stimulated human whole blood measured after 6 hrs post stimulation by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50199033(CHEMBL539342 | CHEMBL214529 | 6-((5S,9R)-9-(4-cyan...)
Affinity DataIC50: 280nMAssay Description:Inhibition of LFA1-mediated IL2 mRNA level in SEB-stimulated human whole blood measured after 6 hrs post stimulation by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-L(Mouse)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50199033(CHEMBL539342 | CHEMBL214529 | 6-((5S,9R)-9-(4-cyan...)
Affinity DataIC50: 150nMAssay Description:Inhibition of LFA1-mediated adhesion of C57BL/6 mouse T cells to ICAM1-expressing TNF-alpha-activated mouse b.END3 cells by calcein-AM staining-based...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50199033(CHEMBL539342 | CHEMBL214529 | 6-((5S,9R)-9-(4-cyan...)
Affinity DataIC50: 20nMAssay Description:Inhibition of LFA1-mediated adhesion of T cell to HUVECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50199033(CHEMBL539342 | CHEMBL214529 | 6-((5S,9R)-9-(4-cyan...)
Affinity DataIC50: 21nMAssay Description:Inhibition of LFA1-mediated adhesion of T cell to HUVECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed