BDBM50197620 CHEMBL3921392::US9815846, Compound 49

SMILES CC(=O)NCc1ncc(NC(=O)c2ccc(c(c2)-c2ccn(C)n2)C(F)(F)F)c(n1)-c1ccccc1

InChI Key InChIKey=SRKKBPIGHIAVHD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50197620   

TargetHigh affinity nerve growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50197620(CHEMBL3921392 | US9815846, Compound 49)
Affinity DataIC50: 4nMAssay Description:Inhibition of TrkA (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50197620(CHEMBL3921392 | US9815846, Compound 49)
Affinity DataIC50: 3.60nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
Go to US Patent