BDBM50197517 (S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyclopentylmethyl}-4-methoxy-butyric acid::CHEMBL225085

SMILES COCC[C@H](CC1(CCCC1)C(=O)NCCCc1ccc(Cl)cc1)C(O)=O

InChI Key InChIKey=UOGBJRPKRSUJRU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50197517   

TargetNeprilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human recombinant NEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50: 10.5nMpH: 7.4Assay Description:Inhibition of human kidney NEP at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of rat NEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50: 2.30nMpH: 7.0Assay Description:Inhibition of human kidney NEP at pH 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of rabbit NEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed