BDBM50196697 1-benzyl-3-(1H-indazol-5-yl)urea::CHEMBL225282::N-benzyl-N0-(1H-5-indazolyl)urea::US9409868, 12

SMILES O=C(NCc1ccccc1)Nc1ccc2[nH]ncc2c1

InChI Key InChIKey=CXBJSHXVWUZPRT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50196697   

TargetRho-associated protein kinase 1 [1-535](Human)
H. Lee Moffin Cancer Center and Research Institute

US Patent
LigandPNGBDBM50196697(1-benzyl-3-(1H-indazol-5-yl)urea | N-benzyl-N0-(1H...)
Affinity DataIC50: 1.39E+4nMpH: 7.5 T: 2°CAssay Description:A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
H. Lee Moffin Cancer Center and Research Institute

US Patent
LigandPNGBDBM50196697(1-benzyl-3-(1H-indazol-5-yl)urea | N-benzyl-N0-(1H...)
Affinity DataIC50: 5.50E+3nMpH: 7.5 T: 2°CAssay Description:A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1/2(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50196697(1-benzyl-3-(1H-indazol-5-yl)urea | N-benzyl-N0-(1H...)
Affinity DataIC50: 260nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50196697(1-benzyl-3-(1H-indazol-5-yl)urea | N-benzyl-N0-(1H...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MCP1-induced cell migration in U937 cells expressing CCR2 by chemotaxis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 2(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50196697(1-benzyl-3-(1H-indazol-5-yl)urea | N-benzyl-N0-(1H...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of ROCK2 after 1 hr by FRET-based enzyme-coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50196697(1-benzyl-3-(1H-indazol-5-yl)urea | N-benzyl-N0-(1H...)
Affinity DataIC50: 1.39E+4nMAssay Description:Inhibition of human His-puritin-tagged ROCK1 expressed in Sf9 cells after 1 hr by FRET-based enzyme-coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed