BDBM50196574 CHEMBL253165::N-[(1S,2R)-1-benzyl-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-3-dibutylsulfamoyl-propionamide

SMILES CCCCN(CCCC)S(=O)(=O)CCC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(OC)c1

InChI Key InChIKey=SORSKESEAHGMMJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50196574   

TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196574(N-[(1S,2R)-1-benzyl-2-hydroxy-3-(3-methoxy-benzyla...)
Affinity DataIC50: 484nMAssay Description:Inhibition of human recombinant BACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196574(N-[(1S,2R)-1-benzyl-2-hydroxy-3-(3-methoxy-benzyla...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human BACE in HEK293 cells by Swedish amyloid inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196574(N-[(1S,2R)-1-benzyl-2-hydroxy-3-(3-methoxy-benzyla...)
Affinity DataIC50: 4.88E+3nMAssay Description:Inhibition of human recombinant cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed