BDBM50195297 1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hydroxy-adamantan-2-yl)-amide::CHEMBL221159

SMILES O[C@@]12C[C@H]3CC(C1)[C@@H](NC(=O)C1(CC1)N1CCCCC1)C(C3)C2

InChI Key InChIKey=CEZQNMXBDYZVET-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50195297   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195297(1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hy...)
Affinity DataIC50: 390nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as inhibition of cortisol formation by fluorescent polarization immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195297(1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hy...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse 11beta-HSD2 assessed as cortisol disappearance by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195297(1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hy...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 11beta-HSD2 assessed as cortisol disappearance by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195297(1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hy...)
Affinity DataKi:  6nMAssay Description:Inhibition of human truncated 11beta-HSD1 assessed as inhibition of radiolabeled cortisone to cortisol conversion by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195297(1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hy...)
Affinity DataKi:  58nMAssay Description:Inhibition of mouse truncated 11beta-HSD1 assessed as inhibition of radiolabeled cortisone to cortisol conversion by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed