BDBM50194756 CHEMBL3961701

SMILES CNCCN1CCC(CC1)OCc1ccccc1

InChI Key InChIKey=HBOJWAYLSJLULG-UHFFFAOYSA-N

Data  2 KI  10 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50194756   

TargetHistone-arginine methyltransferase CARM1(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataKd:  100nMAssay Description:Binding affinity to human PRMT4 in presence of SAH by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataKd:  87nMAssay Description:Binding affinity to human PRMT6 in presence of SAH by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50: 34nMAssay Description:Inhibition of human full length PRMT4 (1 to 608 residues) expressed in 293F cells assessed as inhibition of methylation activity preincubated with pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of PRMT1 (unknown origin) assessed as inhibition of methylation activity measured after 3 hrs using [3H]-SAM by scintillation proximity as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50: 43nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50: 970nMAssay Description:Inhibition of wild-type FLAG-tagged PRMT6 (unknown origin) expressed in HEK293 cells assessed as reduction in H3R2me2a level measured after 20 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of PRMT4 in HEK293 cells assessed as reduction in Med12-Rme2a level measured after 72 hrs by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of PRMT8 (unknown origin) assessed as inhibition of methylation activity measured after 3 hrs using [3H]-SAM by scintillation proximity as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 3 [N508S](Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of PRMT3 (unknown origin) assessed as inhibition of methylation activity measured after 3 hrs using [3H]-SAM by scintillation proximity as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50: 32nMAssay Description:Inhibition of PRMT4 (unknown origin) using histone H3 (21 to 44 residues) as substrate measured after 60 mins in presence of SAM by AlphaLisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50: 34nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50: 34nMAssay Description:Inhibition of PRMT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataKi:  64nMAssay Description:Displacement of [3H]pentazocine from guinea pig sigma1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataKi:  87nMAssay Description:Displacement of [3H]alpha-methylhistamine from human histamine H3 receptor expressed HEK Flp-In cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed