BDBM50194676 1-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea::CHEMBL424719

SMILES CNc1ncc2cc(ccc2n1)-c1cc(NC(=O)Nc2cccc(c2)C(F)(F)F)ccc1C

InChI Key InChIKey=MMJHUKOMQZXIPW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50194676   

TargetTyrosine-protein kinase JAK3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50194676(1-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)phen...)
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of Jak3 by HTRF kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50194676(1-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)phen...)
Affinity DataIC50: 8nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50194676(1-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)phen...)
Affinity DataIC50: 52nMAssay Description:Inhibition of KDR by HTRF kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50194676(1-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)phen...)
Affinity DataIC50: 5nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed