BDBM50193017 CHEMBL3904942::US11155556, No. 17

SMILES CN1c2ccccc2C(=O)N(C)c2cnc(Nc3cccc(c3)S(N)(=O)=O)nc12

InChI Key InChIKey=KCMYPBPMTXEKNF-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50193017   

TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase DCLK1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50: 111nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged DCLK1 (G351 to H689 residues) expressed in Escherichia coli BL21 DE3 using 5-FAM-KKLRRTLSVA-CO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of recombinant human GST-tagged LRRK2 catalytic domain (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase C2 domain-containing subunit gamma(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50: 4nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50: 4nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50: 2nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50: 4nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent