BDBM50192487 (7,8-dimethoxy-10,11-dihydro-5H-2,4,5,11-tetraaza-dibenzo[a,d]cyclohepten-1-yl)-((R)-1-phenyl-ethyl)-amine::CHEMBL379001

SMILES COc1cc2CNc3c(N[C@H](C)c4ccccc4)ncnc3Nc2cc1OC

InChI Key InChIKey=LPWLEMJTQPNOMS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50192487   

TargetEpidermal growth factor receptor(Human)
Imclone Systems

Curated by ChEMBL
LigandPNGBDBM50192487((7,8-dimethoxy-10,11-dihydro-5H-2,4,5,11-tetraaza-...)
Affinity DataIC50: 500nMAssay Description:Inhibition of EGFR autophosphorylation in DiFi cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Imclone Systems

Curated by ChEMBL
LigandPNGBDBM50192487((7,8-dimethoxy-10,11-dihydro-5H-2,4,5,11-tetraaza-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Imclone Systems

Curated by ChEMBL
LigandPNGBDBM50192487((7,8-dimethoxy-10,11-dihydro-5H-2,4,5,11-tetraaza-...)
Affinity DataIC50: 150nMAssay Description:Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed