BDBM50192477 (3-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine::CHEMBL214868

SMILES COc1cc2CNc3c(Nc4cccc(Cl)c4F)ncnc3Oc2cc1OC

InChI Key InChIKey=ZLHZFUUZIUVWJO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50192477   

TargetEpidermal growth factor receptor(Human)
Imclone Systems

Curated by ChEMBL
LigandPNGBDBM50192477((3-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)
Affinity DataIC50: 300nMAssay Description:Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Imclone Systems

Curated by ChEMBL
LigandPNGBDBM50192477((3-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Imclone Systems

Curated by ChEMBL
LigandPNGBDBM50192477((3-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of EGFR autophosphorylation in DiFi cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed