BDBM50191511 2-{4-[4'-chloro-4-(2-oxo-pyrrolidin-1-yl)-biphenyl-2-ylmethoxy]-2-fluoro-phenyl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid::2-{4-[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2-ylmethoxy]-2-fluorophenyl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid::CHEMBL210297

SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(ccc2-c2ccc(Cl)cc2)N2CCCC2=O)cc1F

InChI Key InChIKey=NIBYCXOKANETJM-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50191511   

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2...)
Affinity DataIC50: 61nMAssay Description:Inhibition of HCV 3a NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of HCV 2a NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2...)
Affinity DataIC50: 170nMAssay Description:Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HIV reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of HCV 2b NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2...)
Affinity DataIC50: 62nMAssay Description:Inhibition of HCV 1a NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DNA polymerase gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA polymerase beta(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1)TBA
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2...)
Affinity DataIC50: 8.34E+7nMAssay Description:Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1)TBA
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2...)
Affinity DataIC50: 8.33E+7nMAssay Description:Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article